PUBLICATIONS
BIOFILMS
Heme cross-feeding can augment Staphylococcus aureus and Enterococcus faecalis dual species biofilms.
Ch'ng JH, Muthu M, Chong KKL, Wong JJ, Tan CAZ, Koh ZJS, Lopez D, Matysik A, Nair ZJ, Barkham T, Wang Y, Kline KA. ISME Journal. 2022 (ahead of print) doi: 10.1038/s41396-022-01248-1.
Biofilm-associated infection by enterococci.
Ch'ng JH, Chong KKL, Lam LN, Wong JJ, Kline KA. Nat Rev Microbiol. 2019;17(2):124.
ROSETTES & ADJUNCTIVE TREATMENT
Epitopes of anti-RIFIN antibodies and characterization of rif-expressing Plasmodium falciparum parasites by RNA sequencing.
Ch’ng JH, Sirel M, Zandian A, Quintana MdP, Chan CLS, Moll K, Tellgren-Roth A, Nilsson IM, Qundos U, Nilsson P, Wahlgren M. Scientific Reports 2017; 7, 43190.
Development of drug-loaded immunoliposomes for the selective targeting and elimination of rosetting Plasmodium falciparum-infected red blood cells.
Moles E, Moll K, Ch’ng JH, Parini P, Wahlgren M, Fernandez-Busquets X. Journal of Controlled Release. 2016; 241:57-67
Rosette-disrupting effect of an anti-plasmodial compound for the potential treatment of Plasmodium falciparum malaria complications.
Ch’ng JH, Moll K, Quintana MDP, Chan CLS, Masters E, Moles E, Liu J, Eriksson AB, Wahlgren M. Nature Scientific Reports 2016; 6, 29317
Evasion of immunity to Plasmodium falciparum: Rosettes of blood group A impair recognition of PfEMP1.
Moll K, Palmkvist M, Ch'ng J, Kiwuwa MS, Wahlgren M. PLoS ONE. 2015; 10(12): e0145120.
CHEMOSENSITIZERS & ANTIMALARIALS
Diverted total synthesis of falcitidin acyl tetrapeptides as new antimalarial leads.
Kotturi SR, Somanadhan B, Ch’ng JH, Tan KSW, Buttler MS and Lear MJ. Tetrahedron Letters 2014; 55 (11):1949-1951
A high-content phenotypic screen reveals the disruptive potency of quinacrine and 3',4'-dichlorobenzamil on the digestive vacuole of Plasmodium falciparum.
Lee YQ, Goh SP, Ch'ng JH, Nosten FH, Preiser PR, Pervaiz S, Yadav SK, Tan KS. Antimicrob Agents Chemother. 2013 Nov 11.
A whole cell pathway screen reveals seven novel chemosensitizers to combat chloroquine resistant malaria.
Ch’ng JH, Mok S, Bozdech Z, Lear M, Boudhar A, Russell B, Nosten F, and Tan KSW. Nature Scientific Reports 2013; 3:1734.
PARASITE PROGRAMMED CELL DEATH
Microbial hara-kiri: Exploiting lysosomal cell death in malaria parasites.
Ch’ng JH, Ursing J, Tan KSW. Microbial Cell 2015 ; 2: 57-58.
Validation of a chloroquine-induced cell death mechanism for clinical use against malaria.
Ch’ng JH, Lee YQ, Gun SY, Chia WN, Chang ZW, Wong LK, Batty KT, Russell B, Nosten F, Renia L, Tan KSW. Cell Death Dis 2014 ; 5: e1305.
Can a single “powerless” mitochondrion in the malaria parasite contribute to parasite programmed cell death in the asexual stages?
Ch’ng JH, Yeo SP and Tan KS. Mitochondrion 2013, 13:254-256.
Can we teach an old drug new tricks?
Ch'ng JH, Renia L, Nosten F, Tan KS. Trends Parasitol 2012; 28(6): 220-4.
Drug-induced permeabilization of parasite's digestive vacuole is a key trigger of programmed cell death in Plasmodium falciparum.
Ch'ng JH, Liew K, Goh AS, Sidhartha E, Tan KS. Cell Death Dis 2011; 2: e216.
A programmed cell death pathway in the malaria parasite Plasmodium falciparum has general features of mammalian apoptosis but is mediated by clan CA cysteine proteases.
Ch'ng JH, Kotturi SR, Chong AG, Lear MJ, Tan KS. Cell Death Dis 2010; 1: e26.
OTHERS
SURGE complex of Plasmodium falciparum in the rhoptry-neck (SURFIN4.2-RON4-GLURP) contributes to merozoite invasion.
Quintana MDP, Ch'ng JH, Zandian A, Imam M, Hultenby K, Theisen M, Nilsson P, Qundos U, Moll K, Chan S, Wahlgren M. PLoS One. 2018; 9;13(8):e0201669.
Antibodies in children with malaria to PfEMP1, RIFIN and SURFIN expressed at the Plasmodium falciparum parasitized red blood cell surface.
Quintana MDP, Ch'ng JH, Moll K, Zandian A, Nilsson P, Idris ZM, Saiwaew S, Qundos U, Wahlgren M.
Sci Rep. 2018; 19:8(1):3262.
A translation-enhancing factor triggers pregnancy-associated malaria.
Chan CLS, Frasch A, Mandava CS, Ch’ng JH, Quintana MdP, Vesterlund M, Ghorbal M, Joannin N, Franzen O, Lopez-Rubio JJ, Sanyal S, Wahlgren M. Nature Microbiology. 2017; 2:17068
Frequent GU wobble pairings reduce translation efficiency in Plasmodium falciparum.
Chan CLS, Ch’ng JH, Wahlgren M, Thutkawkorapin J. Scientific Reports. 2017; 7(1):723